The Lyric Theatre, at the city's flagship entertainment venue in Salford Quays, will welcome Her Royal Highness The Princess Royal as guest of honour.
The annual event will take place on Monday, December 5 and alongside Kay, acts set to headline include Britain's Got Talent winner Jai McDowall.
Joining Jai at the 83rd Royal Variety show will be stars from across the pond including X factor USA judge and popstar Nicole Scherzinger and singer Cee-Lo Green.
Fellow Brits will include chart-topping singer Pixie Lott and comedians Jason Manford and Greg Davies.
Performers from new West End show Singin' in The Rain, will also hit the stage along with pop supremos Tony Bennett, Il Divo and Barry Manilow. Aussie funnyman Tim Minchin completes the line up.
Julia Fawcett, The Lowry’s chief executive, said: “The Lowry is delighted to be hosting the 83rd Royal Variety performance.
"This is one of many notable highlights in The Lowry’s 11 year history, which has seen some of the world’s most talented performers take to our stages and finest artists displayed in our galleries. "
The Royal Variety Performance will be screened on ITV1 at a later date.
The Lowry will be closed to visitors from 4pm on Monday, December 5 .
All tickets are only available from the Entertainment Artistes Benevolent Fund on 0208 898 8164. Tweet

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Sold out.
What a c**p line-up, you can tell its being played "up north" and not in London
Couldn't they find a comedian to do it?
A man who used to be quite funny and original, simply isn't any more. Talk about 'resting on your laurels'. Dave Spikey is far funnier, catch him live if you can, hilarious.
just called and sold out months ago via their own advertising.
any other way to get tickets?
Peter Kay eh? What were all that aboat?