Leigh, who are now surely safe on 50 points, can relax for the appealing visit of title-chasing Boston, while Chester have the chance to finally exorcise their relegation demons by condemning Dover to the drop with a Deva Stadium victory over the south coast club.
A win for Southport over visiting Hayes would similarly relegate the Londoners.
Meanwhile, Hyde United, who are now staring relegation from the UniBond Premier Division squarely in the face following Wednesday's goalless draw with Vauxhall, must beat Altrincham at Ewen Fields to maintain their slender hopes of performing a miracle escape.
Top local tussle in Division One is Trafford's Shawe View date with Ashton United.
Ashton need a big finish to earn themselves a place in the league's new end-of-season play-offs.
Radcliffe, who are now in grave danger of letting automatic promotion slip away, can afford no mistakes on their trip to relegation-haunted Stocksbridge. NWCL pacesetters, Salford City, having seen their lead cut to three points in midweek, must win at Warrington to avoid title foes Prescot and Kidsgrove closing in still further.
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