Hamilton led a McLaren 1-2 ahead of team-mate Fernando Alonso in the US Grand Prix , increasing his lead over the Spaniard at the top of the drivers' championship to 10 points.
"What a dream," said the young Brit, who won in Canada last week in his rookie season.
"To come to two circuits that I didn't know and to really come out with such pace and to see the team moving forward is great.
"The first couple of laps were close and then I managed to pull a slight gap.
"In the middle stint my tyres just started to drain and Fernando was right up my tail.
"It was very tough, he fought very well but at the end I managed to pull a gap which I was able to maintain and control the race."
Alonso admitted the Indianapolis race was decided as soon as he failed to overtake Hamilton into the first corner.
Alonso also got alongside Hamilton during the middle of the race but could not force his way past, later swerving towards the pit wall to show his team his displeasure.
Alonso said: "I think the start was the key point of the race, after that who was second would be second in the race.
"I think my start was good but we both braked in more or less the same place, but the start is always risky and I didn't want to crash.
"Eight points are better than nothing, we increased the gap on Ferrari which is one of the main things at this point in the championship."
Alonso had to admit defeat on the second occasion he tried to pass Hamilton.
The Spaniard added: "I tried in the middle stint and we were side by side once on the main straight but it was not enough to overtake him."
The Ferraris of Felipe Massa and Kimi Raikkonen were back in business after a terrible race in Canada, finishing third and fourth. Renault rookie Heikki Kovalainen was once again in the points in fifth with Toyota's Jarno Trulli sixth, while Mark Webber scored his first points of the season with seventh.
Sebastian Vettel, a late stand-in for Robert Kubica in the BMW Sauber, finished eighth on his debut.
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