Nearest rivals Castleford Panthers also tumbled 22-8 to a surprise defeat at Thatto Heath, and saw Leigh East pull level with them.
Chris Hilton and Ian Sampson scored for Mayfield, who were 18-0 down in 14 minutes, and 30-4 at half-time.
Danny Kilshaw was again the inspiration behind Leigh East's 28-8 win at Wigan St Jude's.
After a fairly even first half, East forged ahead to score 18 unanswered points, Kilshaw's second try proving crucial.
Time is running out for Eccles and Salford, who went down 28-10 to Widnes St Maries. A 90-metre interception try by Lee Birdseye just after struggling Eccles had fought back to 10-10, proved the killer.
Leigh Miners lost top spot in the premier with a 30-14 defeat away to West Hull, who regain the spot. Oldham St Anne's gave champions Oulton a run before losing 19-8, while Wigan St Patrick's fell 16-10 at Eastmoor.
Chris Garforth scored three tries as Saddleworth beat Askam to go second in division two.
Tweet

