The Canadian star misses tonight's Carling Cup clash with Hull City and is also ruled out of Saturday's match with Preston.
Manager Paul Jewell is waiting for the outcome of X-rays and a specialist's report after De Vos was injured in the weekend defeat at Millwall.
De Vos was dogged by a foot injury throughout last season and Jewell may have to do without the powerful, experienced central defender for the foreseable future.
Ian Breckin will deputise tonight.
Jewell said: "Hull are a massive club with a huge potential. In Peter Taylor, they have a great manager and a great coach."
Prediction: Wigan Athletic 2 Hull City 0
Will Wigan tame the Tigers? Have your say here.
BETFRED
Match Odds: Wigan 1/2, Draw 5/2, Hull 5/1
Correct score (Wigan to win)
1-0 11/2
2-0 13/2
2-1 8/1
3-0 11/1
3-1 11/1
3-2 22/1
4-0 25/1
4-1 22/1
First/Last scorer
Liddle 7/2
Roberts 7/2
McCulloch 4/1
Bullard 7/1
Dinning 10/1
Kennedy 12/1
Teale 16/1
Jarrett 20/1
Eadan 28/1
Jackson 33/1
Scorecast:
Liddle & Wigan 2-0 22/1
Roberts & Wigan 3-0 40/1
Dinning & Wigan 2-1 66/1
For these and all other bets ring BETFRED on 0800 73 11 210
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