West Ham have completely sold their 7,469 allocation and will take up the whole of the touchline East stand.
A crowd in the region of close on 20,000 is expected.
Veteran star Andy Liddell, who could be on his way in the summer, may be pressed in to an emergency striking role for depleted Latics.
Jason Roberts is serving another suspension and Lee McCulloch picked up leg injuries in the defeat at Nottingham Forest.
The Scot faces a late fitness test but Liddell is on stand-by and won't let Wigan down if given his big chance by manager Paul Jewell. Tweet
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Fellow Latics fans, prepare yourselves to be let down by the Wigan public once again... Call me negative, but I think that our defeat at Forest last week will ensure that most floaters choose the Eastenders omnibus over the Latics.
I will call you negative!