Steve Burr's slick Celts will start as favourites, having thrashed FC's UniBond premier rivals Stocksbridge 7-2 in the last round and having climbed to fifth in Blue Square North.
But Marginson's men, too, are cock-a-hoop in the wake of Wednesday's crushing 4-0 victory over Nantwich.
Marginson, himself a former Stalybridge star, said: "Bridge are a quality side with some quality players. If we're to win, we know we're going to have to be at the top of our game and hope they're not quite at theirs."
FC cup hopes
FC, who have never before reached the Cup's penultimate qualifying stage, are expecting a crowd in excess of 3,000 for a tie which has been put back by 24 hours due to Bury being in action at Gigg Lane.
Meanwhile, in tomorrow's ties involving other North West sides, Andy Preece's Northwich are expected to ease past visiting Chorley, while Radcliffe travel to Workington confident of earning a replay.
Having drawn 2-2 at Hyde in midweek, minnows Salford City will attempt to finish the job at Moor Lane in what promises to be a fascinating second qualifying-round replay.
Elsewhere, on-song Altrincham, unbeaten in their last seven Blue Square Premier starts, take on fourth-placed Mansfield at Moss Lane.
In the day's only Blue Square North fixture, table-topping Droylsden visit lowly Harrogate.
UniBond premier pacesetters Ashton United go to Boston, while, in division one north, promotion hopefuls Curzon Ashton visit Ossett and Trafford entertain Garforth.
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Free Red, Manchester (09/10/2009 at 14:35)
vegas-blue, Stalyvegas (09/10/2009 at 15:42)
Free Red, Manchester (09/10/2009 at 17:53)
Free Red, Manchester (11/10/2009 at 19:47)
The Reds raced into a fantastic 3-1 lead inside the hour but were pegged back by their Blue Square Conference neighbours in an gripping game of football.
Carlos Roca broke the deadlock on 13 minutes and the United faithful were on cloud nine when Phil Marsh doubled the lead 10 minutes before the break. However, Celtic struck back through Matty Barlow four minutes later.
United started the second half just as they had the first and it was no surprised when captain David Chadwick added a third five minutes in. But all credit to Bridge, they kept their heads and fought back with two goals from Joe O’Neill, one of which came from a penalty.
Si, East Manchester, Audenshaw (12/10/2009 at 00:07)
Prestwich Red, Prestwich (12/10/2009 at 09:53)
FC were well worth the 2 goal cushion and could even have improved on this. Stalybridge came back well though and could even have snatched it in the end. I've rarely seen FC pegged back like they were during that second half spell.