While Fergie's Manchester United thoroughbreds will be aiming to make it eight wins in nine matches against Aston Villa, his champion miler Rock of Gibraltar goes for glory in the world's richest horse race.
The most attractive price that Ladbrokes are offering is 25/1 for United to beat Aston Villa 2-0 and Rock of Gibraltar to win by more than two lengths in the world's richest race meeting at Arlington Park in Chicago.
Fresh from their Champions League win over Olympiakos, the Reds are odds on favourites at 1-4 to make it eight wins in nine games against a Villa side that are struggling in the bottom half of the Premiership.
Going for eight in a row
The Rock is 5/4 favourite to win the Breeders Cup Mile and make it an unprecedented eight successive Group One wins.
Therefore, you can get odds of 15/8 for a United win over Villa and victory for Rock of Gibraltar when up against the world's best.
The more adventurous looking for a bigger payout may wish to go for a treble featuring another horse with a United link.
Van Nistelrooy, one of trainer Aiden O'Brien's 10 horses from the Ballydoyle stable racing in the prestigious Chicago event on Saturday evening, is an outsider at 10-1 in the Breeders Cup Juvenile.
So Ladbrokes, the official betting partner of Manchester United, are offering odds of 40-1 on United beating Villa, the Rock winning the Breeders Cup Mile and Van Nistelrooy romping to victory in his race.
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