The Reds' Serbian defender has suffered the unenviable record of being sent off in the last three matches against Rafa Benitez's side.
In September 2008, Vidic was given his marching orders by referee Howard Webb for two yellow cards.
Last spring in the Old Trafford return he hauled down Steven Gerrard and was issued a straight red by Alan Wiley.
And this season he was given two yellows, again at Anfield, this time by Andre Marriner.
"The two at Anfield were definitely influenced by the Liverpool players and the crowd," said Sir Alex.
"I have looked at them again and I don't think they were actually serious. They were yellow cards. But it won't affect him."
On the contrary, the reforming of the Vidic-Rio Ferdinand axis in the middle of the back four is seen by the United manager as a major plus in the run-in.
Torres respect
"What we have seen with Ferdinand and Vidic coming back is a far better stature about the back four for a start," he added.
"Their experience and knowledge of each other's play is down to that. They are looking strong. They will improve because the length of time they have been out, games are going to help them. I am delighted they are both back now."
Vidic had a torrid time containing Fernando Torres at Old Trafford last spring and the Anfield boss Rafa Benitez believes had they had the Spaniard fit all term, Liverpool would be among the title challengers.
"It's possible. I think he is right there," added Fergie.
"He is a top player. When you don't have your top players you don't get top results. It happened to us when all our defenders were injured. We went to Fulham with midfielders playing centre back, what do you expect?
"That was a fragile moment for our club. The back four was changing every game so you don't expect the best results without the best players. That applies to every team.
"With a few coming back we just got over the hill. We climbed over it. I have Jonny Evans and Gary Neville fit.
"Evra has been fantastic this season and getting Edwin van der Sar back was crucial. It does give us a far more solid look."
What is your prediction for the game? Have your say.
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Showing comments 1 to 18 and replies | View All
ribery's ankle, Amsterdam (20/03/2010 at 14:24)
However I DON"T hold my breath!!,..(or perhaps well!!!..)
He has horrors againts the best srtrikers!!
The reason why he will be sold in summer!!
Come On You Reds
ribery's ankle, Amsterdam (20/03/2010 at 14:32)
For me at moment it's a dEfender EVRA who's the man we miss if he doesn't play!!
How MANY games can he consecutively play, I wonder!??
Bigmouth strikes again, Manchester (20/03/2010 at 15:06)
Is It Me? (20/03/2010 at 15:27)
Brian Taylor (20/03/2010 at 15:28)
LEASE ON COUNCIL HOUSE IS 250 YEARS, MANCHESTER (20/03/2010 at 15:39)
Brora boy, Highlands (20/03/2010 at 16:10)
Bill Wirral (20/03/2010 at 16:28)
Rooney had a stinker against Everton but nobody mentions that so why mention a bad game that another player has had. Everyone suffers a loss of form sometime so take that into consideratin as well.
blacksocks, stretfordend (20/03/2010 at 18:29)
Gilly, Belgium (20/03/2010 at 18:29)
I saw Duncan Edwards play, Walton Le Dale (20/03/2010 at 18:30)
Nemanja could do no better than giving Brucie a ring before the game. I recall Brucie once being interviewed before a particular game for us, and he was asked how would he cope with the opponent's striker, he is very fast you know. Brucie replied " Ah, but how fast can he limp"?
Roll on tomorrow!
Forever United (Glazer or not)...., India (20/03/2010 at 18:51)
danny, WILMSLOW (20/03/2010 at 19:19)
red (21/03/2010 at 01:24)
reddevil4ever, India (21/03/2010 at 08:29)
Vanya/Vanja, Montenegro/Crna Gora (21/03/2010 at 08:40)
Ajde Nemanja, pokazi im kako se igra kad je najpotrebnije. Ti si legenda!!!
manc abroad, OT (21/03/2010 at 09:50)
Barry Lee, USA (21/03/2010 at 10:18)