The England striker broke Pompey's resistance with his 23rd goal of the season, equalling a career-best total.
The only surprise, given United's possession, was it took them until the 40th minute to make the breakthrough.
However that goal gave Sir Alex Ferguson's side the impetus they needed and Portsmouth collapsed.
United added a second on the stroke of half time with Nani's effort taking two deflections.
Michael Carrick had similar luck in the second half and Dimitar Berbatov was also on target before Marc Wilson put the ball into his own net.
It was poignant day at Old Trafford as the club commemorated the 52nd anniversary of the Munich Air Disaster in which 23 people, eight of them players, died.
Old Trafford boss Ferguson will no doubt feel the result did the occassion justice.
United began on the front foot and Jonny Evans headed narrowly wide after a cross from the edge of the area by Gary Neville.
Portsmouth, however, launched a swift counter attack and Edwin van der Sar did well to parry a powerful shot from Anthony Vanden Borre.
Rooney tried to work an opening in the 22nd minute but his effort came off the back of Tal Ben Haim and was taken by David James.
Then Nani released Rooney after skipping down the wing in the 33rd minute and he turned quickly only to fire a shot over the bar.
Portsmouth, however, almost opened the scoring a minute later with a spirited response.
Nadir Belhadji got into a good position only to see his effort cleared off the line by Evans and he then failed to make good use of the rebound.
Play switched back down the other end and Berbatov was wasteful in front of the posts.
He somehow managed to turn his effort wide in the 35th minute when it seemed easier to score after Antonio Valencia and Neville cut Portsmouth open.
United did not have to wait long before going ahead and inevitably it was Rooney who scored.
He got on the end of a cross from Darren Fletcher in the 40th minute to send a header beyond James.
United added a second on the stroke of half time, Nani's close range effort taking a deflection first off Anthony Vanden Borre and then James.
The home side restarted in the same vein and Nani sent a shot high over the bar in the 49th minute after a cut-back from Berbatov.
United almost added a third in the 54th minute but James turned Valencia's effort around the post after the winger had played a neat one-two with Berbatov.
Four minutes later James was again cursing his luck as Carrick's drive took a wicked deflection off Michael Hughes and left the goalkeeper stranded.
United maintained the momentum and made it 4-0 on the hour with Berbatov regaining possession and sending a low shot into the corner after Portsmouth failed to close him down.
It was becoming a rout and manager Avram Grant was left scratching his head in disbelief at the way his team had collapsed.
Rooney then picked out Darren Fletcher at the back post but Richard Hughes read the situation well and headed to safety.
Even though United were poised to go back to the top of the table the home supporters were anxious for their side to improve their goals tally.
They got their wish in 69th minute when Wilson turned Patrice Evra's cross into his own net to make it 5-0 to the champions.
Substitute Mame Biram Diouf should have added a sixth goal but skied a shot over the bar in the 80th minute.
United, however, had to be content with a five-star show which was good enough to overtake Chelsea at the top of the table.
Tweet


Showing comments 1 to 25 and replies | View All
Sean , NYXMC (06/02/2010 at 17:24)
roykeane, i always wanted to play for city (not!) (06/02/2010 at 17:26)
LUHG
Crystal Ball (06/02/2010 at 17:34)
All I can say is 'Come on Hull City'. tick tock what?
Roger Harper (06/02/2010 at 17:43)
gordon macniven (06/02/2010 at 18:01)
LEASE ON COUNCIL HOUSE IS 250 YEAR'S, MANCHESTER (06/02/2010 at 18:08)
trured, canada (06/02/2010 at 18:09)
GC Northstand (06/02/2010 at 18:10)
SAF pulls yet another rabbit from the hat, anyone know how the Wastelands muppets went on
BELIEVE
When the seagulls follow the trawler, N Ireland (06/02/2010 at 18:18)
Gilly, Belgium (06/02/2010 at 18:22)
Sean , NYXMC (06/02/2010 at 18:26)
Red Army (06/02/2010 at 18:26)
Good to see the protest gathering speed, pathetic stewards towards the end taking the Glazer Out banner down behind K stand
LUHG
Bigmouth strikes again, Manchester (06/02/2010 at 18:32)
Alias Smith, over the moon (06/02/2010 at 18:35)
tom murphy (06/02/2010 at 18:37)
Britt/Canada (06/02/2010 at 18:51)
Decimated - to kill a large number of something, or to reduce something severely.
Lets not become too picky!!!
danny, WILMSLOW (06/02/2010 at 18:56)
you got back early I agree with your comments!
danny, WILMSLOW (06/02/2010 at 19:03)
Berlin!
gordon macniven (06/02/2010 at 19:05)
Sterling Dingleberry, Useless Washington, DC - USA (06/02/2010 at 19:17)
DUB RED, CLONDALKIN (06/02/2010 at 19:32)
keith brando (06/02/2010 at 19:33)
keith brando dublin
Great Fans Stay To The End..., Manchester (06/02/2010 at 19:36)
up. The fact that we have goals in us from all over the pitch is good.
I APPRECIATE ALL THE FANS WHO KEEP THE FAITH!!!!
GC Northstand (06/02/2010 at 19:40)
Dunc'e my boy you can't be posting notes on facebook, ranting in Norwegian and singing the Wes Brown anthem while the nurse is bringing you a bedpan. Please, old man, at least live some of your life in the real world even if you cannot bring yourself to recognize the qualities of the team and the Godfather of football.
BELIEVE
Shaz Dublin (06/02/2010 at 19:43)
Pull the other one Wilmslow - you saw United's performance of the season and couldn't be bothered to post a single comment?? But cue an article on Anderson and you're there like a shot implying Ferguson doesn't know what he doing. Stick to the blue half pal...