The table-topping Reds go into the clash with confidence high, while Liverpool are in crisis after four defeats on the bounce.
But the city famous for producing Jimmy Tarbuck and Ken Dodd won't be allowing any humour at their expense after banning beach balls from the ground.
The unprecedented ban on inflatables follows Liverpool's defeat last weekend at Sunderland to a freak goal caused by a beach ball on the pitch.
It deflected Darren Bent's shot past baffled goalie Pepe Reina.
Replicas have since become a must-have for rival fans, particularly those at this end of the East Lancs Road hoping to raise a smile at the expense of Liverpool fans.
Liverpool FC's online store quickly sold out of their £10 "beach sets" and today the novelty balls were priced at more than £40 on eBay.
The price hike sparked rumours that United supporters have bought them to flood the Anfield pitch during the game.
Club stewards and police will search fans as usual at Anfield, and confiscate beach balls and other inflatable items.
A Liverpool FC spokesman said: "Any inflatable items will be confiscated at the point of search, whether inside or outside the stadium."
A spokeswoman for Merseyside Police said that there will be no special searches for beach balls, but any found will be confiscated by match day officers.
The balloon controversy has dominated banter among fans nationwide and one mischievous graffiti artist even sprayed on a Betfair billboard advertising bets on the game in Salford: "No Beach Balls", while Salford bookie Fred Done has cheekily offered odds of 1-2 that a beach ball finds its way on to the pitch.
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Showing comments 1 to 25 and replies | View All
Red Bill, Salford (23/10/2009 at 09:04)
United:The team supported by the majority of mancunians (23/10/2009 at 09:08)
A Manc and blue (23/10/2009 at 09:16)
Mickeylove (23/10/2009 at 09:30)
Mickeylove - The Crescent
Macca, Cornwall (23/10/2009 at 09:35)
Maynard Kitchener Lampwick. Manchester., (23/10/2009 at 09:43)
steve wilson (23/10/2009 at 09:52)
P.S. we will not need beach balls to beat the dippers.
Redraw, Belfast (23/10/2009 at 09:58)
MyNameIsEarl, MANCHESTER (23/10/2009 at 10:00)
Scholesy passed me the ball..., England (23/10/2009 at 10:15)
john murray (23/10/2009 at 10:21)
Better than coming to a football match dressed a blue seat
stevi, france (23/10/2009 at 10:32)
mark jones (23/10/2009 at 10:33)
Mancinitaly, Calabria (23/10/2009 at 10:56)
I'm totally deflated!
blue nose 123, Manchester (23/10/2009 at 11:05)
The Original Blue John, London (23/10/2009 at 11:19)
Invisible Man, Manchester (23/10/2009 at 11:21)
Mrs Fullaway`s lodger (23/10/2009 at 11:25)
The Man frae Govan (23/10/2009 at 11:54)
Eike Immel's crossed eyes, Leeds (23/10/2009 at 11:56)
Mike Reed (23/10/2009 at 12:10)
Don't blame it on the moonlight,
Don't blame it the beach ball,
Blame it on Benitez
bluebob81, somerset (23/10/2009 at 12:42)
steve wilson (23/10/2009 at 12:51)
bluebob81, somerset
23/10/2009 at 12:42 Offensive or Inappropriate?
You really are a number 1 prat!
United:The team supported by the majority of mancunians (23/10/2009 at 12:58)
Algernon Blabbermouth, eccles (23/10/2009 at 13:10)
Really really funny and original! And you're from around the corner SOMERSET! Oh the irony! Even so..the cockney Reds are still NEARER to Manchester than YOU! An even bigger irony! Life in your part of Someret must be so sad!