Carlos Tevez may be among the star names that do take part after sitting out Sunday's Manchester derby triumph at Eastlands.
Cristiano Ronaldo is suspended but he would not have played anyway, while Ben Foster is likely to be handed the goalkeeping slot.
Defender Martin Olsson comes back into contention for Blackburn.
Olsson sat out Saturday’s 3-2 loss at Portsmouth through suspension following his dismissal at Spurs the previous week.
Keith Andrews is ineligible, whilst Vince Grella (calf), David Dunn (Achilles) and Steven Reid (knee) remain sidelined through injury.
Manchester United (from): Foster, Kuszczak, Rafael, Evans, Cleverley, Neville, Chester, Vidic, O'Shea, Nani, Park, Fletcher, Anderson, Possebon, Gibson, Giggs, Tevez, Welbeck, Manucho.
Blackburn Rovers (from): Robinson, Brown, Simpson, Ooijer, Samba, Nelsen, Emerton, Khizanishvili, Warnock, Mokoena, Olsson, Tugay, Treacy, Pedersen, Roberts, Derbyshire, Villanueva, Santa Cruz, Fowler, McCarthy.
Which team would you send out? Have your say.
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Gerry, Glastonbury (02/12/2008 at 10:16)