Ronaldo has been widely linked with a move to the Bernabeu since last summer, with Spanish media suggesting the Manchester United winger will be Madrid's number one transfer target at the end of the campaign.
However, United are keen to keep hold of the highly-rated Portugal international, and are currently in talks with the 22-year-old about extending his contract until 2012.
Van Nistelrooy, who played with Ronaldo at Old Trafford, has been hugely impressed with the former Sporting Lisbon player, but the Dutchman is not holding out hope of having him as a team-mate at Madrid next season.
"He is a very good player despite being only 22 years old. The best in the world," Van Nistelrooy said on Spanish radio station Cadena SER.
"Physically and technically he has learned a lot.
"For me it would be good if he came here. But it will be difficult to get Manchester United to let him escape."
When asked if he was compatible with Ronaldo, Van Nistelrooy added: "Yes. In training everything was good. There was chemistry."
Do you think Ronaldo's form has compensated for the loss of Van Nistelrooy? Have your say.
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TMUF, Manchester (23/03/2007 at 10:27)