Isaksson has endured a frustrating campaign with Joe Hart the preferred choice between the posts.
Micah Richards, Nedum Onuoha and Valeri Bojinov remain sidelined for what could be Sven-Goran Eriksson's last match in charge.
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Middlesbrough defender Chris Riggott could keep his place for the game.
Riggott started and scored in last weekend’s 2-0 win over Portsmouth which secured the club’s top-flight status after being recalled from his loan spell at Stoke.
He is likely to figure again with Robert Huth (foot) still missing, while midfielder Mohamed Shawky is out with a back problem which could see him miss Egypt’s summer internationals.
Middlesbrough (from): Schwarzer, Turnbull, Jones, Young, Taylor, Grounds, McMahon, Wheater, Pogatetz, Riggott, Boateng, Arca, Downing, Rochemback, Cattermole, Johnson, Aliadiere, Alves, Tuncay.
Manchester City (from): Isaksson, Elano, Corluka, Ball, Dunne, Jihai, Garrido, Vassell, Caicedo, Gelson, Johnson, Petrov, Ireland, Geovanni, Mwaruwari, Castillo, Logan, Hart.
Last season: Boro 0 City 2
Key opponent: Stewart Downing - Gifted winger with a fierce shot
Prediction: Boro 1 City 1 - It should be a close game if not the most keenly contested
Agree with the prediction? Have your say.
You can get 17/2 on City winning 1-0 with Betfred. For this and more odds, click here.
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(Sam Haggar) SVEN AND FRANK SKY BLUE ARMY COME ON CITY!!! (09/05/2008 at 16:18)
Gk Isaksson
RB Logan CB Corluka CB Dunne LB Ball
RM Vassell CM Johnson CM Fernandes LM Petrov
AM Elano
CF Benjani
subs Hart Hamann Ireland Castilio Sturridge
City win 2-0 Benjabi and Elano
P.S CITY FANS SHOW YOUR SUPPOT FOR SVEN AGAIN
COME CITY!!!