A tactical masterstroke from manager Brian Horton saw a return to form at the Moss Rose.
Though he was jeered for taking off Danny Whitaker and Mike Sheron, Paul Harsley equalised with his first touch of the game.
Fellow substitute John Miles then curled a second four minutes later.
The final nail was hammered home by Graham Potter's left foot as the left wing back made it 3-1 on 82 minutes.
Macclesfield had conceded an awful opener to struggling Grimsby when keeper Steve Wilson had failed to deal with a long punt forward allowing Jason Crowe to slide home the opener. Tweet

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