The two clubs with the Football League's smallest incomes clash in a fixture that normally guarantees goals.
In the six clashes since Accrington regained Football League status, 23 goals have been clocked up, with Stanley notching 2-0 wins in both fixtures last season.
Macc boss Keith Alexander is hoping that on-loan striker Ricky Sappleton has recovered from a groin problem suffered in Saturday's defeat to Bournemouth while Stanley chief John Coleman also has injury problems.
Accrington Stanley league form: WWDLD
Macclesfield league form: WDDDL
Key opponent: Michael Symes - has scored four in four for Stanley
Prediction: Accrington Stanley 2 Macclesfield 2 - stalemate between two struggling sides
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