Needing 319 to make South Africa bat again and therefore stand any chance of avoiding going 1-0 down in this four-match npower series, the hosts were minus Strauss almost immediately.
With 18 overs and two days remaining, they were in dire straits on 13 for one - after a record fifth-wicket stand of 212 between AB de Villiers (174) and Ashwell Prince (149) had carried South Africa to 522 all out.
On a pitch which has largely favoured the batsmen, Ntini found extra bounce from a dangerous line round the wicket with the new ball to have Strauss edging behind.
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