The 36-year-old was walking along Highbury Avenue, in Flixton, when he was set upon by a group of four teenagers.
During the attack, a bottle was smashed over his head. He was taken to hospital after receiving serious cuts to his face.
Four girls, aged 16 and 17, have been arrested on suspicion of assault and bailed pending further investigation.
Det Con Jon Weir, from Stretford CID, said the victim could be left permanently scarred by the attack. He said: "This was a brutal attack that has left this man with serious facial injuries.
"The offenders continued attacking him even as he lay unconscious on the floor."
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