Kevin Geoffrey Flynn, 34, of Whinberry Road, Broadheath was due before magistrates today.
Police were called to St Brendan's Road North in Withington at 9.30pm on Wednesday after reports a man had been stabbed at a house in the street.
The injured man was taken to Manchester Royal Infirmary but pronounced dead on arrival. He has not yet been formally identified.
A 56-year-old man arrested on suspicion of murder has since been released without charge and a 27-year-old arrested on suspicion of assisting an offender has been bailed until February 15 pending further inquiries.
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