The owner of newspapers including The Sun, The Times, The News of the World and The Sunday Times said "significant" job losses would result from the changes, which will take place over the next five years.
News International's plans will see it invest in state-of-the-art full colour printing presses at Enfield, north London and at sites in Glasgow and Knowsley,.
The investment comes 18 years after a bitter industrial dispute over News International's switching of printing from Fleet Street to Wapping.
Les Hinton, executive chairman of News International, said there would be no impact on jobs for at least two years and that staff reductions would be achieved through voluntary redundancies wherever possible. It currently employs about 1,000 print production staff.
Mr Hinton said the new presses would provide colour on every page and bring advantages to advertisers and editorial, including through later deadlines.
He added: "When this project is complete our newspapers will be unsurpassed in the quality of their printing and the speed and efficiency with which we produce them."
News International, which is the main UK subsidiary of global media company News Corporation, said editorial and commercial staff would remain at Wapping. Tweet
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