Altrincham-based entrepreneurs Giles Harridge and John Smith established the company after they met at ante-natal classes.
They invested £75,000 initially in their business baby, which now offers more than 2,000 gifts ranging from personalised bottles of champagne to customised books and cards, and experience days to wedding gifts.
The duo used the £75,000 to develop and market a personalised calendar, with the recipient's name spelled out in photographs.
Mr Smith said: "I had seen how popular personalised calendars were in the business world - I used to send them to clients and I thought it would work as a gift for anyone, and these were the first items we marketed.
"They have proved to be immensely popular ever since.
"The success of GettingPersonal.co.uk has came as a surprise to us both, and winning this award is recognition of all the hard work that the whole of our team has put in over the past three years."
Mr Smith had previously been working for north west technology company Avaya, while Mr Harridge worked for Altrincham-based traffic information business ITIS Holdings.
Since 2005, GettingPersonal.co.uk has grown into a multi-million pound operation with 23 full-time employees.
The company now has over 125,000 customers - many of whom have been drawn to their website through word of mouth.
Mr Harridge said: "Year-on-year sales for GettingPersonal.co.uk were up 200 per cent in April to £3.2m, and we anticipate that these will grow to £7.2m over the coming year.
"It's been an exciting time for us over the past three years and we are now looking forward to the future - I think that it is fair to say that the potential of the internet is immense.
"We intend to looking at the potential to create a strong presence in Europe."
The market intelligence company Hitwise reported that GettingPersonal.co.uk was the fastest growing online gift retailer in 2007 - measured by visitor numbers. It attracted 2.8 million in 2007.
The M.E.N. Business Awards have been a growth area for online businesses. LateRooms.com won the award in 2006, one month before it was bought by First Choice for £120m.
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