Andy Goddard, who is based at the company's regional headquarters in Oldham Street, Denton, said TNT Post would invest around £1m in its northern business - covering the north west, Yorkshire and the north east - over the next 12 months.
The firm has bought 18 vans as it gears up for expansion and aims to have a fleet of around 50 vehicles by the end of 2008.
It is recruiting drivers, sales staff and head office employees as part of the growth plan.
TNT Post is on target to handle 200m items of mail across the north this year, more than double the 2007 figure.
It specialises in collecting, sorting and delivering invoices, direct mailings and brochures for businesses.
Customers include Swinton Insurance, Kensington Finance Management Consultants, and Stockport Primary Care Trust.
Mr Goddard, 50, of Stalybridge, said: "Greater Manchester is a key area for us as we look to develop our business in the north."
He established TNT Post in the region in March 2006 and has increased revenues from £1m in that year. The company has trialled a new service, TNT-it, in the region and is planning to roll it out in other areas later this year.
It enables SMEs to send letters via computer, which TNT Post then prints and delivers.
Nick Wells, national chief executive of TNT Post, said: "Businesses in Greater Manchester, large and small, are reaping the benefits of postal liberalisation, and we are delighted that we are able to invest in our Denton operation to expand our service. Our growing success in Greater Manchester is testament to the level of service, flexibility and value for money we can provide local SMEs."
As well as its Denton hub, the firm has a sorting centre in Ashton-in-Makerfield, Wigan. It is currently trialling postal deliveries on foot in Liverpool.
TNT Post, whose UK headquarters are in Marlow, is one of the leading challengers to Royal Mail in the deregulated postal market. Rivals include DHL and UK Mail.
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